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Calcium Phosphate Microspheres as a Delivery Vehicle for Tooth-Bleaching Agents.

T Mellgren1, T Qin1, C Öhman-Mägi1

  • 11 Materials in Medicine Group, Division of Applied Materials Science, Department of Engineering Sciences, Uppsala University, Uppsala, Sweden.

Journal of Dental Research
|November 11, 2017
PubMed
Summary

Calcium phosphate microspheres show promise for safer tooth whitening. These remineralizing agents can be added to bleaching gels without hindering peroxide diffusion, potentially reducing tooth sensitivity and enamel demineralization.

Keywords:
dental enameldiffusionperoxidetooth remineralizationtooth sensitivitytooth whitening

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Area of Science:

  • Dental materials science
  • Biomaterials engineering
  • Cosmetic dentistry

Background:

  • Tooth bleaching with hydrogen and carbamide peroxide is prevalent in cosmetic dentistry.
  • Common side effects include tooth sensitivity and enamel demineralization.
  • Existing research on peroxide diffusion lacks standardized, replicable conditions.

Purpose of the Study:

  • To investigate the use of calcium phosphate microspheres as an additive in bleaching gels.
  • To determine if microspheres hinder bleaching agent diffusion.
  • To assess microspheres as potential carriers for carbamide peroxide.

Main Methods:

  • A diffusion model was developed to measure hydrogen peroxide flux and diffusivity.
  • Three whitening gels with varying microsphere concentrations were formulated.
  • Hydrogen peroxide flux was measured through bovine enamel discs under steady-state conditions.

Main Results:

  • Calcium phosphate microspheres can serve as carriers for carbamide peroxide.
  • The concentration of microspheres did not impact peroxide diffusivity through enamel.
  • The developed diffusion model allows for direct comparison with future studies.

Conclusions:

  • Calcium phosphate microspheres are a promising additive for bleaching gels.
  • Microspheres can enhance bleaching safety by minimizing side effects like sensitivity and demineralization.
  • Further research can utilize the standardized diffusion model for material development.