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Progress in developing transgenic monkey model for Huntington's disease.

Brooke R Snyder1, Anthony W S Chan2,3

  • 1Biology Department, Jefferson State Community College, 2601 Carson Road, Birmingham, AL, 35215, USA. brookersnyder@gmail.com.

Journal of Neural Transmission (Vienna, Austria : 1996)
|November 12, 2017
PubMed
Summary
This summary is machine-generated.

Transgenic Huntington's disease (HD) monkeys offer a valuable model for studying this neurodegenerative disorder. Their progression closely mirrors human patients, aiding preclinical research and therapeutic development.

Keywords:
Comparative animal modelsHuntington’s diseaseNonhuman primatesTransgenic animal model

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Area of Science:

  • Neuroscience
  • Genetics
  • Primate Models

Background:

  • Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by striatal degeneration, leading to motor, cognitive, and psychiatric impairments.
  • Current treatments manage symptoms but do not halt or reverse HD neuropathology.
  • Existing cell and rodent models have limitations in fully replicating HD's complex progression.

Purpose of the Study:

  • To review the development of a transgenic Huntington's disease (HD) rhesus macaque model.
  • To highlight the utility of this nonhuman primate model for understanding HD pathogenesis.
  • To discuss opportunities for preclinical studies and outcome measure assessment in HD research.

Main Methods:

  • Longitudinal study of transgenic HD rhesus macaques.
  • Magnetic resonance imaging (MRI) to assess brain atrophy and white matter integrity.
  • Behavioral assessments of cognitive and psychiatric functions.

Main Results:

  • HD monkeys exhibit progressive brain atrophy and white matter changes consistent with human HD.
  • Cognitive decline in corticostriatal functions and neuropathology are observed.
  • HD monkeys display behavioral changes like increased anxiety and aggression, mirroring human HD symptoms.

Conclusions:

  • The transgenic HD monkey model closely replicates human Huntington's disease progression.
  • This primate model offers a unique platform for preclinical research and evaluating translatable outcome measures.
  • Further development and utilization of HD monkeys are crucial for advancing Huntington's disease research and therapeutic strategies.