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Updated: Feb 19, 2026

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

Published on: October 11, 2024

Primary Graft Dysfunction After Lung Transplantation.

Mary K Porteous¹, James C Lee²

¹Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA.

Clinics in Chest Medicine

|November 13, 2017

Summary

This summary is machine-generated.

Primary graft dysfunction is acute lung injury after transplantation, causing significant mortality. Understanding its causes, like ischemia reperfusion and immune activation, is key to improving patient outcomes.

Keywords:

Acute lung injury Ischemia-reperfusion injury Lung transplantation Primary graft dysfunction

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Last Updated: Feb 19, 2026

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

Published on: October 11, 2024

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

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Published on: July 10, 2012

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

Area of Science:

Pulmonary Medicine
Transplantation Immunology
Critical Care

Background:

Primary graft dysfunction (PGD) is a severe complication following lung transplantation.
It significantly contributes to short- and long-term patient morbidity and mortality.

Purpose of the Study:

To provide a comprehensive review of primary graft dysfunction.
To cover its epidemiology, pathogenesis, risk factors, prevention, and treatment.

Main Methods:

Literature review of primary graft dysfunction.
Synthesis of current knowledge on PGD mechanisms and management.

Main Results:

PGD involves multiple complex mechanisms including ischemia reperfusion injury, cellular damage, and inflammation.
Risk factors, preventive strategies, and therapeutic approaches are discussed.

Conclusions:

Effective management of PGD requires a multifaceted approach targeting its diverse pathogenic pathways.
Further research is needed to optimize prevention and treatment strategies for PGD.