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The Urticaria Activity Score-Validity, Reliability, and Responsiveness.

Tomasz Hawro1, Tatevik Ohanyan1, Nicole Schoepke1

  • 1Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.

The Journal of Allergy and Clinical Immunology. in Practice
|November 13, 2017
PubMed
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This summary is machine-generated.

The Urticaria Activity Score 7 (UAS7) and its twice-daily version (UAS7TD) are reliable tools for assessing chronic spontaneous urticaria. Both versions demonstrate comparable validity and sensitivity to change, aiding in treatment monitoring.

Area of Science:

  • Dermatology
  • Clinical Trials
  • Health Outcomes Research

Background:

  • Chronic spontaneous urticaria (CSU) presents with fluctuating symptoms.
  • Disease activity is measured using the Urticaria Activity Score (UAS).
  • Two versions of the UAS7 exist: once-daily (UAS7) and twice-daily (UAS7TD).

Purpose of the Study:

  • To evaluate the clinimetric properties of both UAS7 versions.
  • Assess validity, reliability, sensitivity to change, minimal important difference (MID), and smallest detectable change (SDC).

Main Methods:

  • 130 adult CSU patients completed UAS7, UAS7TD, and other patient-reported outcome measures.
  • Assessments were conducted before and after omalizumab therapy.
  • Physician Global Assessment was also collected.
Keywords:
Chronic inducible urticariaChronic spontaneous urticariaDisease activityMinimal important differencePatient-reported outcomeQuality of lifeReliabilityReproducibilityResponsivenessSmallest detectable changeUrticaria Activity ScoreValidity

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Main Results:

  • Both UAS7 versions showed high correlation with patient and physician global assessments and the UCT.
  • Internal consistency was respectable for both wheal and pruritus scores.
  • Changes in UAS7 and UAS7TD correlated well with changes in other measures, indicating good sensitivity to change.

Conclusions:

  • UAS7 and UAS7TD possess comparable and robust clinimetric properties.
  • Both versions demonstrate good sensitivity to change and similar minimal important differences.
  • These findings support the use of both UAS7 versions for CSU management.