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Related Experiment Videos

Injectable network biomaterials via molecular or colloidal self-assembly.

Jugal Kishore Sahoo1, Michael A VandenBerg1, Matthew J Webber2

  • 1Department of Chemical and Biomolecular Engineering, University of Notre Dame, IN 46556, USA.

Advanced Drug Delivery Reviews
|November 13, 2017
PubMed
Summary

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Injectable biomaterials created through self-assembly offer advantages over traditional implants. These advanced materials can be injected and assemble in the body, revolutionizing tissue engineering and drug delivery.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Regenerative Medicine

Background:

  • Self-assembly is a key strategy for developing advanced functional materials.
  • Injectable biomaterials bypass surgical implantation, offering significant medical advantages.
  • Existing research explores self-assembled biomaterials using peptides, proteins, and nanoparticles.

Purpose of the Study:

  • To review the strategies and mechanisms of self-assembled injectable biomaterials.
  • To highlight the applications of these materials in various medical fields.
  • To project the future impact of self-assembled biomaterials in healthcare.

Main Methods:

  • Exploration of self-assembly strategies utilizing engineered oligopeptides, proteins, and nanoparticles.
Keywords:
Biomimetic materialsColloidal materialsControlled releaseHost-guest complexesHydrogelsMetal-ligand chemistrySupramolecular biomaterials

Related Experiment Videos

  • Investigation of affinity-mediated crosslinking of synthetic precursors.
  • Analysis of in situ self-assembly triggered by physiological stimuli.
  • Evaluation of shear-thinning and self-healing properties for injectability.

    • Main Results:

    • Self-assembled biomaterials can be injected via in situ assembly or through shear-thinning and self-healing properties.
    • These materials demonstrate significant utility in tissue engineering, regenerative medicine, drug delivery, and immunoengineering.
    • The controlled and multifunctional nature of self-assembled materials is highlighted.

    Conclusions:

    • Injectable self-assembled biomaterials represent a promising advancement in medical applications.
    • Their unique properties facilitate minimally invasive procedures and targeted therapies.
    • Future developments are expected to significantly improve healthcare practices.