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Updated: Aug 12, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Patients with schizophrenia have a higher risk of psoriasis: A systematic review and meta-analysis
Patompong Ungprasert1, Karn Wijarnpreecha2, Wisit Cheungpasitporn3
1Mayo Clinic, Rochester, MN, USA; Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj hospital, Mahidol University, Bangkok, Thailand.
Abstract:
Recent studies have suggested an increased risk of psoriasis among patients with schizophrenia although the results are still inconclusive. This systematic review and meta-analysis of cohort and case-control studies that compared the risk psoriasis among patients with schizophrenia versus subjects without schizophrenia was conducted to better characterize the risk. Pooled relative risks and 95% confidence intervals from the included studies were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. After a comprehensive literature review, 2 retrospective cohort studies and 4 case-control studies with approximately 6.1 million participants were identified. The meta-analysis found that the risk of psoriasis among patients with schizophrenia was significantly higher than non-schizophrenia subjects. Subgroup analysis by study design revealed a significantly higher risk in both cohort study and case-control study subgroup.
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