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Updated: Feb 19, 2026

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
[Fertility and deep infiltrating endometriosis]
Jonathan Cohen1, Emmanuelle Mathieu d'Argent1, Lise Selleret1
1Assistance publique-Hôpitaux de Paris, université Pierre-et-Marie-Curie Paris 6, hôpital Tenon, GRC6-UPMC : centre expert en endométriose (C3E), service de gynécologie-obstétrique et médecine de la reproduction, 75020 Paris, France.
Abstract:
Deep infiltrating endometriosis is the most severe form of the disease, defined by infiltration beneath the peritoneum greater than 5mm. It affects several anatomical locations including the bladder, the vesico-uterine cul-de-sac, the torus uterinum, the uterosacral ligament, rectovaginal septum and the colon-rectum. Deep infiltrating endometriosis is associated with infertility. Surgery performed for deep infiltrating endometriosis in the context of pain offers good pregnancy rates either spontaneously or after assisted reproductive technologies. The results are less favorable when digestive tract is involved. IVF performed in the context of deep infiltrating endometriosis allows very satisfactory results and does not entail risks of aggravation of the pathology. There is currently no clear evidence to support either IVF or surgery to manage infertility associated with deep infiltrating endometriosis, but patients should be informed, although a risk of severe complication exists, that surgery is the only way to increase the chances of spontaneous fertility.
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