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Updated: Feb 18, 2026

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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TMEM106a is a Novel Tumor Suppressor in Human Renal Cancer

Chenglong Wu1, Juan Xu2, Han Wang3

  • 1Shenzhen Second People's Hospital, Guangzhou Medical University, Shenzhen, China.

Kidney & Blood Pressure Research
|November 14, 2017
PubMed
Abstract

Insights

Transmembrane protein 106A (TMEM106a) acts as a tumor suppressor in renal cancer. Its reduced expression in kidney tumors correlates with increased proliferation and migration, highlighting its potential as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Renal cancer diagnosis and management are evolving, but underlying mechanisms remain unclear.
  • Transmembrane protein 106A (TMEM106a) regulates macrophage activation and is linked to poor prognosis in gastric cancer.
  • The specific role of TMEM106a in renal cancer was previously unknown.

Purpose of the Study:

  • To investigate the expression and function of TMEM106a in renal cancer.
  • To determine if TMEM106a acts as a tumor suppressor or oncogene in kidney cancer.

Main Methods:

  • Analyzed TMEM106a expression in renal cancer cell lines and primary tissues.
  • Overexpressed TMEM106a in a low-expression renal cancer cell line using viral vectors.
  • Assessed cell proliferation, migration, and apoptosis following TMEM106a manipulation.
  • Confirmed findings using siRNA knockdown in primary renal cells.

Main Results:

  • TMEM106a expression was significantly lower in renal cancer cells than in normal renal cells.
  • Restoring TMEM106a expression reduced proliferation and migration while enhancing apoptosis.
  • TMEM106a knockdown in normal cells increased colony formation, suggesting a tumor-suppressive role.

Conclusions:

  • TMEM106a functions as a novel tumor suppressor in renal cancer.
  • TMEM106a's role in regulating cell growth and apoptosis suggests potential therapeutic applications.
Keywords:
ApoptosisCell migrationProliferationRenal cancerTMEM106a

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