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Protein-Based 3D Microstructures with Controllable Morphology and pH-Responsive Properties.

Shuxin Wei1, Jie Liu2, Yuanyuan Zhao3

  • 1School of Chemical Engineering and Technology, Tianjin University , No. 135 Yaguan Road, Haihe Education Park, Jinnan District, Tianjin 300350, P. R. China.

ACS Applied Materials & Interfaces
|November 14, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed pH-responsive 3D microstructures using bovine serum albumin (BSA) and two-photon polymerization. These tunable protein microstructures show potential for biomedical applications and biosensors.

Keywords:
3D microstructurebovine serum albuminmorphologypH responsetwo-photon polymerization

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Area of Science:

  • Biomaterials Engineering
  • Microfabrication Technology
  • Nanotechnology

Background:

  • Controlling stimuli-responsive biomaterials at the micrometer scale is vital for advanced biomedical applications.
  • Protein-based microstructures offer unique biocompatibility and tunable properties.

Purpose of the Study:

  • To fabricate and characterize three-dimensional (3D) bovine serum albumin (BSA)-based microstructures with tunable morphology and pH-responsive behavior.
  • To explore the potential of these microstructures in applications like microparticle separation and biosensing.

Main Methods:

  • Utilized two-photon polymerization microfabrication technology to create 3D BSA microstructures.
  • Optimized laser processing parameters (laser power, scanning speed, layer distance) for precise fabrication.
  • Investigated the pH-responsive swelling behavior and tunable morphology of the BSA microstructures.

Main Results:

  • Achieved well-defined 3D BSA microstructures with tunable surface morphology.
  • Demonstrated a wide range of pH response with swelling ratios from 1.08 to 2.71.
  • Fabricated a reversible pH-responsive panda face microrelief and a mesh sieve for microparticle separation with tunable pore sizes.

Conclusions:

  • BSA-based 3D microstructures fabricated via two-photon polymerization exhibit controllable morphology and significant pH-responsive properties.
  • The swelling behavior is influenced by BSA precursor concentration, with a proposed mechanism.
  • These protein microstructures hold promise for applications in biomedicine and biosensors, particularly for microparticle separation and sensing.