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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
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Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
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Nonalcoholic Fatty Liver Disease.

Patrick H Sweet1, Teresa Khoo2, Steven Nguyen2

  • 1Family Medicine, University of California, Riverside, 555 Tachevah Drive, 2E-204, Palm Springs, CA 92262, USA.

Primary Care
|November 15, 2017
PubMed
Summary

Nonalcoholic fatty liver disease (NAFLD) is a growing global health issue characterized by liver fat accumulation. Early detection and lifestyle changes are key to managing this condition and preventing severe liver damage.

Keywords:
DyslipidemiaInsulin resistanceLiver diseaseMetabolic diseaseNonalcoholic fatty liver disease (NAFLD)Nonalcoholic steatohepatitis (NASH)Steatosis

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Area of Science:

  • Hepatology
  • Internal Medicine
  • Public Health

Background:

  • Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions characterized by fat accumulation in the liver.
  • Its global prevalence is rising, posing a significant public health challenge.
  • NAFLD often presents asymptomatically or with non-specific symptoms like fatigue.

Purpose of the Study:

  • To define Nonalcoholic fatty liver disease (NAFLD) and its clinical presentation.
  • To outline diagnostic approaches for NAFLD.
  • To summarize current management strategies and treatment indications for advanced disease.

Main Methods:

  • Review of the definition and clinical features of NAFLD.
  • Discussion of diagnostic modalities including imaging and liver biopsy.
  • Overview of treatment principles for NAFLD.

Main Results:

  • NAFLD is defined by hepatic steatosis, potentially with injury, and is increasingly common worldwide.
  • Diagnosis often relies on incidental findings from elevated liver enzymes or imaging.
  • Liver biopsy is essential for assessing inflammation severity.

Conclusions:

  • The primary treatment for NAFLD involves lifestyle modifications such as weight loss and managing comorbid conditions like diabetes and hyperlipidemia.
  • Liver transplantation is reserved for cases that progress to cirrhosis.