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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
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Nuclear sirtuins and inflammatory signaling pathways
Keila Lopes Mendes1, Deborah de Farias Lelis2, Sérgio Henrique Sousa Santos3
1Laboratory of Health Science, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil; Instituto Federal de Minas Gerais (IFMG), Ouro Preto, Minas Gerais, Brazil.
Cytokine & Growth Factor Reviews
|November 15, 2017
Summary
Nuclear sirtuins (SIRT1-7) regulate chronic inflammation by suppressing key inflammatory pathways. Targeting these enzymes offers a promising strategy for treating inflammatory diseases.
Area of Science:
- Biochemistry
- Molecular Biology
- Immunology
Background:
- Chronic inflammation contributes to diseases like arthritis, diabetes, and obesity.
- Sirtuins (enzymes regulating gene transcription epigenetically) are crucial in cellular processes.
- Nuclear sirtuins (SIRT1, SIRT2, SIRT6, SIRT7) are implicated in inflammatory response regulation.
Purpose of the Study:
- To review the roles of nuclear sirtuins in regulating inflammatory reactions.
- To highlight the therapeutic potential of nuclear sirtuins in chronic inflammatory diseases.
Main Methods:
- Review of existing scientific literature on nuclear sirtuins and inflammation.
- Analysis of studies detailing the molecular mechanisms of SIRT1, SIRT2, SIRT6, and SIRT7 in inflammation.
Main Results:
- SIRT1 suppresses NF-κb, decreases COX-2 and iNOS, and increases antioxidant gene expression.
- SIRT2 deacetylates the NF-κβ p65 subunit and RIP-1.
- SIRT6 interacts with NF-κβ promoter regions to repress transcription; SIRT7's absence increases inflammation.
Conclusions:
- Nuclear sirtuins play significant roles in controlling chronic inflammation.
- Targeting nuclear sirtuins presents a potential therapeutic avenue for managing inflammatory disorders.
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