[Comparative evaluation of the transport of transit hepatotropic compounds based on mathematical modelling]

Specific features of kinetics by the hepatobiliary system 131I-BR, 131I-BS, 99mTc-pVIDA and 99mTc-NIDA have been shown. There is a definite pattern for all coefficients: a1,2 greater than a2,1; a2,1 greater than a2,3 less than a3,4. In this case the phase of absorption (a1,2) six times exceeded that of isolation of an indicator from hepatocytes (a2,3). The main feature consists in the augmented speed of the passage of indicators through hepatocytes in the following sequence: 131I-BR----131I-BS----99mTc-pVIDA----99mTc-NIDA. A three-chamber reversible model is suitable for various hepatotropic compounds.