Natural Products with Heteroatom-Rich Ring Systems
Emma K Davison1, Jonathan Sperry1
1School of Chemical Sciences, University of Auckland , 23 Symonds Street, Auckland 1142, New Zealand.
Journal of Natural Products
|November 15, 2017
Summary
This review explores natural products featuring rare, heteroatom-rich rings (three or more heteroatoms in 5-7 membered rings). It details their isolation, biological activities, and biosynthesis.
Area of Science:
- Medicinal Chemistry
- Natural Product Chemistry
- Organic Chemistry
Background:
- Natural products are a vital source of novel chemical scaffolds.
- Heterocyclic compounds are prevalent in biologically active molecules.
- Complex heterocyclic ring systems present synthetic and biosynthetic challenges.
Purpose of the Study:
- To comprehensively review known natural products with heteroatom-rich ring systems.
- To discuss the isolation, biological activities, and biosynthesis of these compounds.
- To highlight the structural diversity and significance of these rare heterocycles.
Main Methods:
- Literature search for natural products containing specific heterocyclic motifs.
- Analysis of reported isolation procedures and characterization data.
- Review of studies on biological activities and biosynthetic pathways.
Main Results:
- Identification of numerous natural products with 5-, 6-, and 7-membered rings containing three or more heteroatoms.
- Summary of diverse biological activities associated with these compounds.
- Elucidation of various biosynthetic strategies for constructing these complex heterocycles.
Conclusions:
- Heteroatom-rich natural products represent a unique class of molecules with significant biological potential.
- Understanding their biosynthesis provides insights into enzymatic catalysis and molecular assembly.
- These compounds serve as valuable leads for drug discovery and chemical biology.
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