Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

929
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
929
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

362
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
362
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

2.7K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
2.7K
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

608
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
608
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

714
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
714
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

375
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
375

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expanding the <i>MRPS34</i> Genotype-Phenotype Correlation: Two Novel Cases and a Cohort Review.

JIMD reports·2026
Same author

Factors associated with response to rituximab in patients with immune thrombocytopenia.

HemaSphere·2026
Same author

The association of thrombocytopenia with haematological malignancy.

British journal of haematology·2026
Same author

Improved survival with fludarabine-based therapies in mixed phenotype acute leukaemia: A population-based study using the WHO 2022 classification.

British journal of haematology·2026
Same author

Incidence and Survival of Hemophagocytic Lymphohistiocytosis Over Two Decades: A Population-Based Study.

European journal of haematology·2026
Same author

Venetoclax combinations in untreated CLL: 5-year results and patient-reported outcomes analysis of the CLL13/GAIA trial.

Blood·2026

Related Experiment Video

Updated: Feb 18, 2026

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
04:40

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

Published on: November 4, 2022

1.4K

Splenomegaly - Diagnostic validity, work-up, and underlying causes.

Emelie Curovic Rotbain1, Dennis Lund Hansen1, Ove Schaffalitzky de Muckadell2

  • 1Department of Haematology, Odense University Hospital, Odense, Denmark.

Plos One
|November 15, 2017
PubMed
Summary
This summary is machine-generated.

The ICD-10 code for splenomegaly in the Danish National Registry of Patients is valid, with hematological diseases most frequently identified as the cause. However, a significant portion of patients lacked a definitive diagnosis, suggesting potential under-coding.

More Related Videos

Application of Microwave Ablation in Laparoscopic Partial Splenectomy
03:49

Application of Microwave Ablation in Laparoscopic Partial Splenectomy

Published on: November 15, 2024

566
Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

839

Related Experiment Videos

Last Updated: Feb 18, 2026

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
04:40

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

Published on: November 4, 2022

1.4K
Application of Microwave Ablation in Laparoscopic Partial Splenectomy
03:49

Application of Microwave Ablation in Laparoscopic Partial Splenectomy

Published on: November 15, 2024

566
Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

839

Area of Science:

  • Medical informatics
  • Hematology
  • Hepatology

Background:

  • Splenomegaly is a frequent finding in internal medicine referrals.
  • Causes range widely, including hematological diseases and liver cirrhosis.
  • Some cases remain undiagnosed despite thorough investigation.

Purpose of the Study:

  • Validate the accuracy of the ICD-10 splenomegaly diagnosis code in the Danish National Registry of Patients (DNRP).
  • Identify underlying diseases causing splenomegaly in a Danish cohort.
  • Assess the utility of registry data for splenomegaly research.

Main Methods:

  • Retrospective review of 129 patients with an ICD-10 splenomegaly code from the DNRP (1994-2013).
  • Exclusion of patients with prior splenomegaly, hematological malignancies, or liver cirrhosis.
  • Calculation of the positive predictive value (PPV) for the splenomegaly code and investigation of underlying causes.

Main Results:

  • The splenomegaly diagnosis code demonstrated a high overall PPV of 92%.
  • Hematological diseases accounted for 39% of causal diagnoses, followed by hepatic (18%) and infectious (10%) diseases.
  • A substantial 25% of patients had no identified causal diagnosis for their splenomegaly.

Conclusions:

  • The ICD-10 code for splenomegaly is reliable for use in registry-based studies.
  • Under-coding may affect the representativeness of registry data; supplementary sources could be beneficial.
  • While hematological conditions are common causes, a significant proportion of splenomegaly cases remain unexplained.