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Thrombospondin-1 is a multifaceted player in tumor progression
Tingting Huang1, Li Sun1, Xianglin Yuan1
1Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Oncotarget
|November 16, 2017
Summary
Thrombospondin-1 (TSP1), an extracellular matrix protein, plays a complex role in tumor microenvironments. Its effects on angiogenesis, tumor cell behavior, and immunity vary, impacting cancer progression.
Area of Science:
- Extracellular matrix biology
- Tumor microenvironment research
- Cancer immunology
Background:
- Thrombospondins are a family of extracellular matrix (ECM) proteins.
- Thrombospondin-1 (TSP1) is a key component of the tumor microenvironment.
- TSP1's functions are mediated by interactions with cell surface molecules.
Purpose of the Study:
- To review the multifaceted roles of TSP1 in tumor progression.
- To discuss TSP1's impact on angiogenesis, tumor cell behavior, and immunity.
- To explore the clinical implications of TSP1-related compounds.
Main Methods:
- Literature review of TSP1 functions in cancer.
- Analysis of TSP1's interactions with cellular and molecular components.
- Discussion of clinical studies involving TSP1.
Main Results:
- TSP1 acts as an angiogenesis inhibitor by affecting endothelial cells.
- TSP1 influences tumor cell adhesion, invasion, migration, proliferation, and apoptosis.
- TSP1 modulates tumor immunity.
- TSP1's effects are context-dependent, varying with the microenvironment.
Conclusions:
- TSP1 exhibits diverse and sometimes opposing effects on tumor progression.
- The composition of the tumor microenvironment dictates TSP1's impact.
- TSP1-based therapies hold potential clinical implications for cancer treatment.
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