Related Experiment Video
Updated: Feb 18, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Optimising the value of the evidence generated in implementation science: the use of ontologies to address the
Susan Michie1, Marie Johnston2
1Centre for Behaviour Change, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK. s.michie@ucl.ac.uk.
Abstract:
Implementing research findings into healthcare practice and policy is a complex process occurring in diverse contexts; it invariably depends on changing human behaviour in many parts of an intricate implementation system. Questions asked with the aim of improving implementation are multifarious variants of 'What works, compared with what, how well, with what exposure, with what behaviours (for how long), for whom, in what setting and why?'. Relevant evidence is being published at a high rate, but its quantity, complexity and lack of shared terminologies present challenges. The achievement of efficient, effective and timely synthesis of evidence is facilitated by using 'ontologies' to systematically structure and organise the evidence about constructs and their relationships, using a controlled, well-defined vocabulary.
More Related Videos
Related Concept Videos
Ethics in Research
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
Guidelines for Writing Outcome
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
Nursing Clinical Information System
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
The Evidence for Evolution
Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...

