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The first decade of advanced cell therapy clinical trials using perinatal cells (2005-2015)
Pedro S Couto1, Alexey Bersenev2, Frances Verter1
1Parent's Guide to Cord Blood Foundation, Brookeville, MD 20833, USA.
Aim:
The first review of advanced cell therapy trials with perinatal cells.
Materials & Methods:
We compiled 281 clinical trials of advanced cell therapy with perinatal cells that were registered in 2005-2015.
Results:
The most common cell source in these trials is cord blood, but the cell type that provides the mechanism of action in the majority of trials is mesenchymal stem/stromal cells. We analyze trends among the 15 parameters we compiled for these trials.
Conclusion:
Advanced cell therapy with perinatal cells is a new field that covers a wide range of diagnoses but where most of the trials are early Phase. Researchers in different countries tend to work with a preferred cell source and cell type.
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