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Related Experiment Videos

Topical methotrexate therapy for psoriasis.

G D Weinstein1, J L McCullough, E Olsen

  • 1Department of Dermatology, University of California, Irvine 92717.

Archives of Dermatology
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

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Topical methotrexate, enhanced by laurocapram (Azone), effectively treats psoriasis. This formulation significantly improved erythema, scale, and elevation in patients with plaque psoriasis.

Area of Science:

  • Dermatology
  • Pharmacology
  • Biochemistry

Background:

  • Methotrexate is used for psoriasis.
  • Percutaneous penetration of topical drugs can be a challenge.
  • Laurocapram (Azone) is a penetration enhancer.

Purpose of the Study:

  • To evaluate the efficacy of topical methotrexate formulations containing laurocapram (Azone) for plaque psoriasis.
  • To assess the impact of different concentrations of topical methotrexate on psoriasis symptoms.

Main Methods:

  • In vitro and in vivo studies demonstrated enhanced percutaneous penetration of methotrexate with laurocapram.
  • A two-center, double-blind, pilot clinical study involving 42 patients with plaque psoriasis.
  • Patients applied topical methotrexate (0.1%, 0.5%, 1%) or vehicle twice daily for six weeks, with weekly lesion scoring for erythema, scale, and elevation.

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Main Results:

  • Topical methotrexate formulations with laurocapram showed significant improvement in psoriasis symptoms compared to vehicle alone.
  • Overall improvement of 50% or more in combined erythema, scale, and elevation scores was observed in 64% (0.1% MTX), 59% (0.5% MTX), and 56% (1% MTX) of patients.
  • Vehicle alone resulted in improvement in 25% of patients.

Conclusions:

  • Topical methotrexate formulations enhanced with laurocapram (Azone) demonstrate potential for treating plaque psoriasis.
  • Adequate percutaneous absorption of methotrexate is crucial for therapeutic benefit in psoriasis management.
  • These preliminary findings support further investigation of topical methotrexate for psoriasis.