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Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
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KLHL6 Is Preferentially Expressed in Germinal Center-Derived B-Cell Lymphomas
Christian A Kunder1, Giovanna Roncador2, Ranjana H Advani3
1Department of Pathology.
American Journal of Clinical Pathology
|November 16, 2017
Summary
KLHL6 protein is highly expressed in germinal center B cells and B-cell lymphomas. Immunohistochemistry for KLHL6 can aid in classifying B-cell lymphomas, distinguishing germinal center types from others.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- KLHL6 is a BTB-Kelch protein selectively expressed in lymphoid tissues.
- KLHL6 shows strongest expression in germinal center B cells.
Purpose of the Study:
- To characterize KLHL6 expression in normal and neoplastic tissues.
- To evaluate KLHL6 as a potential diagnostic marker for B-cell lymphomas.
Main Methods:
- Gene expression profiling and immunohistochemistry were used to analyze KLHL6 expression.
- Protein expression was assessed in 1,058 hematopoietic neoplasms.
Main Results:
- KLHL6 was positive in 95% of follicular lymphomas, a germinal center-derived neoplasm.
- B-cell lymphomas of non-germinal center origin, such as CLL/SLL, MZL, and MCL, were generally negative for KLHL6.
Conclusions:
- KLHL6 immunohistochemistry is a valuable tool for diagnosing B-cell lymphomas.
- KLHL6 can serve as an adjunct marker alongside BCL6, CD10, HGAL, and LMO2 for lymphoma classification.
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