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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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New Insights into Lymphoma Pathogenesis.

Kojo S J Elenitoba-Johnson1,2, Megan S Lim1,3

  • 1Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email: kojo.elenitoba-johnson@uphs.upenn.edu , megan.lim@uphs.upenn.edu.

Annual Review of Pathology
|November 16, 2017
PubMed
Summary
This summary is machine-generated.

Recent advances in molecular biology and sequencing have significantly improved our understanding of lymphoma pathogenesis. This knowledge is revolutionizing lymphoma diagnosis, treatment, and personalized medicine approaches.

Keywords:
circulating tumor DNAlymphomametabolismmutationspathogenesisspliceosome

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Lymphomas are clonal lymphocyte proliferations classified by maturity and lineage.
  • Understanding lymphoma pathogenesis is crucial for diagnosis and patient management.

Purpose of the Study:

  • To discuss recent scientific and technologic advances impacting lymphoma research.
  • To explore novel concepts challenging existing lymphoma biology paradigms.
  • To highlight the implications for diagnosis, treatment, and personalized medicine.

Main Methods:

  • Review of advancements in immunology, cytogenetics, molecular biology, gene expression profiling, proteomics, and next-generation sequencing over 30 years.
  • Discussion of emerging concepts in lymphoma biology.

Main Results:

  • Significant enhancement in understanding lymphoma pathogenetic mechanisms.
  • Identification of novel concepts impacting lymphoma classification and biology.

Conclusions:

  • Advances are transforming lymphoma diagnosis, molecular testing, and disease monitoring.
  • New insights are driving drug development and personalized medicine strategies for lymphoma.
  • The evolving understanding of lymphoma biology necessitates updated approaches to patient care.