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Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells

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Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers.

Yunfeng Yan^1,2, Hu Xiong², Xinyi Zhang²

¹College of Biotechnology and Bioengineering, Zhejiang University of Technology , Hangzhou, Zhejiang 310014, China.

Biomacromolecules

|November 16, 2017

Summary

Researchers developed new polymeric nanoparticles for messenger RNA (mRNA) delivery. These nanoparticles efficiently deliver mRNA to the lungs, showing promise for treating pulmonary diseases.

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Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

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Published on: February 1, 2019

Area of Science:

Biotechnology
Materials Science
Nanomedicine

Background:

Messenger RNA (mRNA) therapeutics offer broad potential but face delivery challenges.
Effective and safe delivery systems are crucial for mRNA-based therapies.

Purpose of the Study:

To develop efficient polymeric delivery carriers for mRNA.
To optimize nanoparticle formulation for enhanced mRNA delivery and stability.

Main Methods:

Screening a library of 480 modified poly(trimethylolpropane allyl ether-co-suberoyl chloride) polyesters.
Formulating mRNA polyplex nanoparticles (NPs) with Pluronic F127 and evaluating stability and potency.
Assessing luciferase expression in IGROV1 cells and in mouse lungs after intravenous injection.

Main Results:

Identified lead polyesters for mRNA delivery.
Optimized Pluronic F127 content to 5% for balancing NP stability and delivery potency.
Achieved predominant luciferase expression in mouse lungs using 5% F127 formulated PE4K-A17-0.33C12 mRNA NPs.

Conclusions:

Developed a robust approach for creating efficient mRNA delivery carriers.
Demonstrated targeted lung delivery of mRNA using degradable polymeric nanoparticles.
Highlighted the potential of these carriers for treating pulmonary diseases.