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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

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Statins in Aortic Disease

Vicky Tsigkou1, Gerasimos Siasos1, Eva Mpletsa1

  • 1Department of Cardiology, 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens,Greece.

Current Pharmaceutical Design
|November 17, 2017
PubMed

Insights

Statins offer cardiovascular benefits for aortic diseases, improving endothelial function and plaque stability. Further research is needed to determine optimal statin types and doses for specific aortic conditions.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Aortic Diseases

Background:

  • Statins exhibit pleiotropic effects, enhancing cardiovascular health by improving endothelial dysfunction, reducing inflammation, and stabilizing atherosclerotic plaques.
  • Aortic diseases encompass conditions like aortic valve stenosis, regurgitation, aneurysms, and genetic disorders, with statins showing cardio-protective potential.

Purpose of the Study:

  • To review current data on the use of statins in treating various aortic diseases.
  • To synthesize existing evidence regarding statin therapy's role in managing aortic conditions.

Main Methods:

  • A comprehensive literature search was performed using PubMed and the Cochrane Database.
  • Identification of studies and recent articles focusing on statin use in aortic disease.

Main Results:

  • Evidence from animal and human studies largely supports beneficial effects of statins in aortic diseases.
  • Some conflicting data exists, necessitating careful interpretation of current findings.

Conclusions:

  • Further investigation is required to establish optimal statin types and dosages for specific aortic disease clinical scenarios.
  • Personalized statin therapy recommendations for aortic diseases warrant additional research.
Abstract

Keywords:
Aortic diseaseHMG-CoA- inhibitorscardiovascular diseasesendothelial dysfunctioninflammationstatins

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