Related Experiment Video
Updated: Feb 18, 2026
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Patch testing in Israeli children with suspected allergic contact dermatitis: A retrospective study and literature
Yaron Zafrir1, Akiva Trattner2,3, Emmillia Hodak2,3
1Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel.
Insights
Nickel allergy is prevalent in Israeli children with suspected allergic contact dermatitis, particularly in girls. Patch testing is recommended for diagnosis, irrespective of atopic status.
Area of Science:
- Pediatric Dermatology
- Allergology
- Contact Dermatitis
Background:
- Childhood allergic contact dermatitis presents a significant clinical challenge.
- Understanding allergen prevalence in pediatric populations is crucial for effective management.
Purpose of the Study:
- To determine the rate of positive patch tests in Israeli children with suspected allergic contact dermatitis.
- To analyze sex and age-related differences in patch test results.
- To compare pediatric findings with adult data and existing literature.
Main Methods:
- Retrospective analysis of 343 children (aged 1-18) undergoing patch testing with a standard pediatric series.
- Inclusion of data on clinical characteristics and patch test outcomes from 1999 to 2012.
- Standard pediatric series of 23 allergens used for patch testing.
Main Results:
- 28.6% of children showed at least one positive patch test reaction.
- Nickel sulfate was the most common allergen, followed by potassium dichromate and cobalt chloride.
- Nickel sensitivity was higher in girls, especially those under 3 and over 12 years old.
Conclusions:
- Nickel is the primary allergen in Israeli children with suspected allergic contact dermatitis, with higher prevalence in girls.
- Patch testing is valuable for diagnosing allergic contact dermatitis in children, even those without atopic dermatitis.
Background/Objectives:
Childhood allergic contact dermatitis is recognized as a significant clinical problem. The objective was to evaluate the rate of positive patch tests in Israeli children with clinically suspected allergic contact dermatitis, identify possible sex and age differences, compare results with those in Israeli adults, and review pediatric studies in the literature.
Methods:
The study sample included 343 children and adolescents (197 female, 146 male; 1-18 years of age, mean age 11.8 years) with clinically suspected allergic contact dermatitis who underwent patch testing with a standard pediatric series of 23 allergens at a tertiary medical center from 1999 to 2012. Data on clinical characteristics and test results were collected retrospectively from the medical files.
Results:
Ninety-eight subjects (28.6%) (75 girls [38.1%], 23 boys [15.8%]) had at least one positive reaction. The most frequent reactions were to nickel sulfate, followed by potassium dichromate and cobalt chloride. Nickel sulfate sensitivity was more common in girls, especially those younger than 3 years and older than 12 years. The prevalence of contact sensitization was similar in subjects with and without atopic dermatitis (50% and 51%, respectively).
Conclusion:
Nickel is the most common allergen in Israeli children, especially girls. Patch testing should be performed in children with clinically suspected allergic contact dermatitis regardless of atopic background.
More Related Videos
09:32Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
07:10Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
Published on: April 21, 2019
Related Concept Videos
02:06Allergic Reactions
01:30Drug Toxicity: Allergic Reactions
01:27Allergic Drug Reactions
01:30Allergic Reactions: Anaphylaxis