Impact of marital status on outcomes following ST-segment elevation myocardial infarction
Moo Hyun Kim1, Kwang Min Lee2, Soo Jin Kim3
1Department of Cardiology, Dong-A University Medical Center, Busan, Republic of Korea; Clinical Trial Center, Dong-A University Medical Center, Busan, Republic of Korea.
Insights
Being married is associated with better cardiovascular outcomes and survival after ST-elevation myocardial infarction (STEMI) in Korean patients. This study highlights the importance of marital status for predicting major adverse cardiovascular events (MACE) in STEMI survivors.
Area of Science:
- Cardiology
- Social Science
- Public Health
Background:
- Mood disorders, depression, and loneliness are known risk factors for thrombotic occlusions.
- Marital status may influence cardiovascular outcomes and survival post-ST-segment elevation myocardial infarction (STEMI), but evidence in Asian populations is limited.
Purpose of the Study:
- To investigate the association between marital status and cardiovascular outcomes in Korean patients with STEMI.
- To compare major adverse cardiovascular events (MACE) and mortality rates between married and widowed, divorced, or single (WDS) patients after STEMI.
Main Methods:
- Retrospective analysis of 980 Korean patients with STEMI, categorized into married (n=780) and WDS (n=200) groups.
- 1:1 matching for age and gender resulted in 172 patients per group.
- Clinical characteristics and 1-year prognosis, including MACE and death, were collected and analyzed.
Main Results:
- Widowed, divorced, or single (WDS) patients experienced significantly more MACE (44 vs. 26; p=0.016) and deaths (32 vs. 19; p=0.049) at 1 year compared to married patients.
- WDS patients also had a shorter time to MACE occurrence (p=0.018).
- No significant differences were observed in revascularization, stroke, major bleeding, or overall survival between the groups.
Conclusions:
- Marital status appears linked to 1-year MACE and survival following STEMI in Korean patients.
- Being married may be associated with improved vascular outcomes compared to being WDS.
- Further large-scale studies, including national registries, are needed to validate these findings and extend the evidence beyond East Asian populations.
Background:
Mood disorders, depression, and loneliness are established risk factors for thrombotic occlusions. Social relationships in general, and marital status in particular may play a role in predicting cardiovascular outcomes and survival after ST-segment elevation myocardial infarction (STEMI), but the evidence is inconclusive especially in Asians.
Methods:
The Korean patients presented with STEMI (n=980) constituted married (n=780); or widowed, divorced, or single (WDS, n=200) groups. After the matching for age, and gender, the groups were matched 1:1, with each group containing 172 patients. Clinical characteristics and STEMI prognosis such as major adverse cardiovascular events (MACE) and death at 1year, in married versus WDS patients were collected, and retrospectively analyzed.
Results:
Overall, the total of 70 non-fatal MACE and 51 deaths occurred. At 1-year, the WDS patients exhibited significantly more MACE (44 vs.26; p=0.016), deaths (32 vs. 19; p=0.049) and shorter time to MACE occurrence (p=0.018), compared to the married patients. There were no differences in revascularization, cerebral infarction, cerebral bleeding, major bleeding, coronary artery bypass graft, early mortality and the overall survival between groups.
Conclusion:
Marital status may be linked to 1-year MACE including survival following STEMI, while being married may improve vascular outcomes compared to WDS in Korean patients. Further larger cohort or/and uniformed national registry studies are required to validate these data, and expand the evidence beyond East Asians.
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