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Retroperitoneal Inflammatory Myofibroblastic Tumor: Case Report and Immunohistochemistry Study
Sonia Ziadi1, Mounir Trimeche1, Sarra Mestiri1
1Departments of Pathology, CHU Farhat-Hached, Tunisia.
World Journal of Oncology
|November 18, 2017
Summary
This case report details a rare retroperitoneal inflammatory myofibroblastic tumor (IMT) in a 41-year-old man. The tumor showed p53 overexpression, and the patient experienced an unfavorable outcome despite biopsy.
Area of Science:
- Oncology
- Pathology
Background:
- Inflammatory myofibroblastic tumors (IMT) are rare neoplasms with unknown causes.
- Retroperitoneal IMTs are exceptionally uncommon, presenting diagnostic and therapeutic challenges.
Observation:
- A 41-year-old male presented with abdominal pain, indicative of a retroperitoneal mass.
- Magnetic resonance imaging identified a tumor adjacent to the pancreas, stomach, and major vessels.
- The tumor was deemed unresectable, necessitating a laparotomy and biopsy.
Findings:
- Histopathological analysis confirmed an inflammatory myofibroblastic tumor.
- The tumor exhibited overexpression of the p53 protein.
- Tests for Epstein-Barr virus and Human Herpesvirus-8 were negative.
Implications:
- This case highlights the unpredictable clinical course of retroperitoneal IMTs.
- p53 overexpression may be a relevant biomarker in IMT.
- The unfavorable outcome underscores the need for further research into IMT etiology and treatment.
