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Hydrostatic pressure of the suprachoroidal space
K Emi1, J E Pederson, C B Toris
1Department of Ophthalmology, University of Minnesota, Minneapolis 55455.
Investigative Ophthalmology & Visual Science
|February 1, 1989
Summary
Suprachoroidal pressure, crucial for uveoscleral outflow, was measured in monkey eyes. Higher intraocular pressure (IOP) increased the pressure difference, driving fluid from the anterior chamber.
Area of Science:
- Ophthalmology
- Physiology
Background:
- Uveoscleral outflow is a significant pathway for aqueous humor drainage.
- Understanding suprachoroidal space pressure is vital for comprehending this outflow mechanism.
Purpose of the Study:
- To measure hydrostatic pressure in the suprachoroidal space of cynomolgus monkey eyes.
- To investigate the relationship between intraocular pressure (IOP) and suprachoroidal pressure.
Main Methods:
- Simultaneous measurement of IOP and suprachoroidal pressure using direct cannulation or silicone sponge implantation in 18 monkey eyes.
- IOP was varied between 5 and 60 mm Hg.
Main Results:
- Suprachoroidal pressure was consistently below IOP.
- Anterior suprachoroidal (supraciliary) space pressure was 0.8 mm Hg below IOP; posterior suprachoroidal pressure was 3.7 mm Hg below IOP.
- Increased IOP led to a greater pressure differential between the anterior chamber and posterior suprachoroidal space.
Conclusions:
- The pressure differential between the anterior chamber and posterior suprachoroidal space increases with IOP.
- This pressure differential acts as the driving force for uveoscleral outflow.