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Updated: Feb 18, 2026

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
Published on: March 10, 2023
The JAK2V617F and CALR exon 9 mutations are shared immunogenic neoantigens in hematological malignancy
Morten Orebo Holmström1,2, Hans Carl Hasselbalch1, Mads Hald Andersen2,3
1Department of Hematology, Zealand University Hospital.
Abstract:
Approximately 90% of patients with the hematological malignancies termed the chronic myeloproliferative neoplasms harbor either the JAK2V617F-mutation or CALR exon 9 mutation. Both of these are recognized by T-cells, which make the mutations ideal targets for cancer immune therapy as they are shared antigens.
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