Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Circuits01:25

Neural Circuits

2.9K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
2.9K
Neuronal Communication01:28

Neuronal Communication

3.7K
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
3.7K
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.9K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.9K
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

2.5K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.5K
The Synapse02:47

The Synapse

133.9K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
133.9K
Synaptic Signaling01:09

Synaptic Signaling

6.8K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues.

bioRxiv : the preprint server for biology·2026
Same author

Reticulon-1 synthesis controls outgrowth and microtubule dynamics in injured cortical axons.

Life science alliance·2026
Same author

Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo.

Brain stimulation·2025
Same author

Alpha-synuclein abundance and localization are regulated by the RNA-binding protein PUMILIO1.

Cell reports·2025
Same author

FUS Mislocalization Rewires a Cortical Gene Network to Drive Cognitive and Behavioral Impairment in ALS.

medRxiv : the preprint server for health sciences·2025
Same author

Modulation of CREB3L2-ATF4 heterodimerization via proteasome inhibition and HRI activation in Alzheimer's disease pathology.

Cell death & disease·2025
Same journal

Application of Bioactive Natural Compounds to Promote Cell Proliferation and Migration in the Wound Healing Process.

Results and problems in cell differentiation·2026
Same journal

Mechanobiology of Myelin Generation/Regeneration in Health and Disease.

Results and problems in cell differentiation·2026
Same journal

Epigenetic Regulation of RUNX2 in Bone Mechanobiology.

Results and problems in cell differentiation·2026
Same journal

Integrating Mechanical Loading, Mechanotransduction, and Biological Responses in Musculoskeletal Tissues Across the Lifespan: Regulation Influenced by Cells, Extracellular Matrix, and Sex.

Results and problems in cell differentiation·2026
Same journal

Ciliary-Mediated Mechanotransduction in Skeletal Development and Diseases.

Results and problems in cell differentiation·2026
Same journal

Modulation of the Mechanosensory Matrisome by Serotonergic Signaling.

Results and problems in cell differentiation·2026
See all related articles

Related Experiment Video

Updated: Feb 18, 2026

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings
10:24

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings

Published on: January 10, 2015

17.9K

Tctp in Neuronal Circuitry Assembly.

Cláudio Gouveia Roque1, Christine E Holt2

  • 1The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. cag2230@cumc.columbia.edu.

Results and Problems in Cell Differentiation
|November 18, 2017
PubMed
Summary
This summary is machine-generated.

Translationally controlled tumor protein (TCTP) is crucial for axon development in the brain. TCTP deficiency impairs axonal projections by disrupting mitochondrial function and survival signaling.

More Related Videos

Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons
10:50

Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons

Published on: November 2, 2018

52.3K
Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

13.7K

Related Experiment Videos

Last Updated: Feb 18, 2026

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings
10:24

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings

Published on: January 10, 2015

17.9K
Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons
10:50

Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons

Published on: November 2, 2018

52.3K
Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

13.7K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • The function of Translationally controlled tumor protein (TCTP) in neurons remained largely unknown despite its known expression in the brain.
  • Previous assumptions of TCTP being primarily in mitotic cells and its low abundance in the brain limited research into its neuronal roles.
  • Recent studies highlight tctp mRNA enrichment in neuronal axons, suggesting a potential role in neural circuit development.

Purpose of the Study:

  • To investigate the role of TCTP in the development of axon projections within vertebrate retinal circuits.
  • To elucidate the molecular mechanisms by which TCTP influences axon growth and survival.

Main Methods:

  • Utilized genome-wide profiling to identify tctp mRNA localization in neuronal axons.
  • Investigated the effects of TCTP deficiency on axon development and survival in retinal circuits.
  • Analyzed mitochondrial function and density in TCTP-deficient axons.

Main Results:

  • TCTP is essential for the accurate and timely development of axon projections in retinal circuits.
  • TCTP deficiency leads to compromised pro-survival signaling in axons.
  • TCTP-deficient axons exhibit mitochondrial dysfunction and reduced mitochondrial density.
  • These deficits impair the metabolic state required for normal axon guidance and extension.

Conclusions:

  • TCTP plays a critical role in supporting axon survival and development through its association with pro-survival pathways.
  • Mitochondrial dysfunction and metabolic inadequacy are key consequences of TCTP loss in developing axons.
  • These findings reveal an unexplored function of TCTP in the intricate process of neuronal wiring.