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Related Concept Videos

Asepsis01:28

Asepsis

3.5K
The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
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Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
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Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
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Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

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Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
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A Data-Driven Approach to Quantifying Immune States in Sepsis
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A Data-Driven Approach to Quantifying Immune States in Sepsis

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Sepsis Definitions: A Work in Progress.

John C Marshall1

  • 1Departments of Surgery and Critical Care Medicine, St. Michael's Hospital, 4th Floor Bond Wing, Room 4-007, 30 Bond Street, Toronto, ON M5B 1W8, Canada.

Critical Care Clinics
|November 19, 2017
PubMed
Summary
This summary is machine-generated.

Sepsis, a complex disorder, has evolved in definition over two millennia. Recent Sepsis-3 criteria define it as a dysregulated immune response causing life-threatening organ dysfunction from infection.

Keywords:
EpidemiologyOrgan dysfunctionSepsisShockStratificationSystemic inflammatory response syndrome

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Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Immunology

Background:

  • The term
  • sepsis
  • has a long history, evolving from describing invasive infections to the host's response.
  • The Sepsis-3 definition refines understanding, emphasizing dysregulated immunity and organ dysfunction.

Purpose of the Study:

  • To review the historical evolution of sepsis definitions.
  • To discuss the limitations of past and current sepsis characterizations.
  • To highlight the Sepsis-3 definition's focus on immune dysregulation and organ dysfunction.

Main Methods:

  • Literature review of historical and contemporary sepsis definitions.
  • Analysis of the conceptual shifts in understanding sepsis.
  • Synthesis of the Sepsis-3 criteria and its implications.

Main Results:

  • Sepsis definitions have evolved significantly over centuries.
  • The Sepsis-3 definition represents a paradigm shift, focusing on the host response.
  • Current definitions highlight life-threatening organ dysfunction due to a dysregulated immune response.

Conclusions:

  • Understanding sepsis has progressed from infection-centric to host-response-centric.
  • The Sepsis-3 definition provides a more precise framework for a complex disorder.
  • Continued research is needed to address the limitations in characterizing sepsis.