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Updated: Feb 12, 2026

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
[Pathogenesis, genetics and diagnosis of endometriosis]
Emile Daraï1, Stéphane Ploteau2, Marcos Ballester1
1Assistance publique-Hôpitaux de Paris, université Pierre-et-Marie-Curie (UPMC), Paris 6, hôpital Tenon, service de gynécologie-obstétrique et reproduction humaine, 75020 Paris, France; Hôpital Tenon, centre expert en endométriose (C3E), groupe de recherche clinique (GRC-6 UPMC), 75020 Paris, France; UMRS-938 Paris 6, 75012 Paris, France; Hôpital Tenon, centre de diagnostic en un jour de l'endométriose (CDJE), 75020 Paris, France.
Abstract:
Endometriosis is a multifactorial pathology. Trans-tubal reflux theory remains valid. Genetic and epigenetic factors associated with immunological perturbations are involved. The role of endocrine disruptors is discussed although epidemiological studies are contradictory. Therapeutics are primarily based on hormonal treatments but better understanding of pathophysiology should allow targeted non-hormonal therapy. The clinical examination is sometimes negative, which should not eliminate the diagnosis and imposes complementary examinations as best as possible by referents.
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