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Related Experiment Video

Updated: Feb 18, 2026

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
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Quantitative angle-insensitive flow measurement using relative standard deviation OCT.

Jiang Zhu1, Buyun Zhang, Li Qi1

  • 1Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA.

Applied Physics Letters
|November 21, 2017
PubMed
Summary
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A new relative standard deviation OCT (RSD-OCT) method maps vascular networks and quantifies blood flow velocities. This angle-insensitive technique overcomes limitations of traditional Doppler OCT for in vivo measurements.

Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Vascular Biology

Background:

  • Optical Coherence Tomography (OCT) offers high-resolution angiography but lacks quantitative flow velocity data.
  • Doppler OCT for velocity measurement is challenged by complex vascular networks and Doppler angle determination.

Purpose of the Study:

  • To introduce a novel Relative Standard Deviation OCT (RSD-OCT) method.
  • To enable quantitative blood flow velocity measurements independent of Doppler angles.
  • To simultaneously map vascular networks and quantify flow velocities in vivo.

Main Methods:

  • Developed and applied the Relative Standard Deviation OCT (RSD-OCT) technique.
  • Utilized angle-insensitive RSD values for flow velocity quantification.
  • Validated the method in a rat cortex model for in vivo imaging.

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Related Experiment Videos

Last Updated: Feb 18, 2026

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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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Main Results:

  • RSD-OCT provides angle-insensitive measurements across a wide range of Doppler angles.
  • A nearly linear relationship was observed between RSD values and blood flow velocities.
  • Successfully mapped vascular networks and quantified flow velocities in a rat cortex.

Conclusions:

  • RSD-OCT is a promising technique for non-invasive, quantitative blood flow assessment.
  • This method overcomes key limitations of existing OCT-based velocity measurements.
  • RSD-OCT facilitates simultaneous vascular mapping and in vivo flow quantification.