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Renal-Clearable PEGylated Porphyrin Nanoparticles for Image-guided Photodynamic Cancer Therapy
Liang Cheng1,2, Dawei Jiang2, Anyanee Kamkaew2,3
1Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
Advanced Functional Materials
|November 21, 2017
Abstract:
Noninvasive dynamic positron emission tomography (PET) imaging was used to investigate the balance between renal clearance and tumor uptake behaviors of polyethylene glycol (PEG)-modified porphyrin nanoparticles (TCPP-PEG) with various molecular weights. TCPP-PEG10K nanoparticles with clearance behavior would be a good candidate for PET image-guided photodynamic therapy.
Keywords:
Dynamic PET imagingFluorescence imagingPhotodynamic therapyRenal clearanceTCPP-PEG nanoparticles
