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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
Published on: November 4, 2015
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[Pulmonary tumor thrombotic microangiopathy].
M Merad1, A Alibay1, S Ammari2
1Service d'urgence en oncologie médicale, Gustave-Roussy Cancer Campus Grand Paris, Villejuif, 94805 Villejuif cedex, France.
Revue Des Maladies Respiratoires
|November 21, 2017
Summary
Pulmonary tumor thrombotic microangiopathy is a rare syndrome where tumor cells cause lung microvascular damage, leading to heart and respiratory failure. Early diagnosis is challenging, but chemotherapy may offer survival benefits.
Area of Science:
- Cardiovascular Medicine
- Pulmonary Medicine
- Oncology
Background:
- Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare clinicopathological syndrome.
- It involves tumor cell micro-emboli in pulmonary circulation, causing thrombotic microangiopathy.
- PTTM can lead to respiratory failure and acute or sub-acute right heart failure.
Observation:
- Histological findings include micro tumor emboli in lung vasculature.
- Thrombus formation and intimal proliferation are associated with these emboli.
- Diagnosis before death is extremely difficult, with most data from autopsies.
Findings:
- Rare pre-mortem diagnoses suggest potential chemotherapy effectiveness.
- The syndrome's pathophysiology and clinical course require further elucidation.
- Interdisciplinary research is crucial for understanding PTTM.
Implications:
- Targeted therapies may improve the prognosis of PTTM.
- Improved understanding could lead to longer survival, potentially weeks or months.
- Enhanced collaboration between pathologists and clinicians is essential for advancing PTTM research.
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