Related Experiment Video
Updated: Feb 18, 2026
Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
Published on: April 4, 2019
Broncho-Vaxom in pediatric recurrent respiratory tract infections: A systematic review and meta-analysis
Ju Yin1, Baoping Xu1, Xiantao Zeng2
1Department of Respiratory, Beijing Children's Hospital, Capital Medical University, China National Clinical Research Center for Respiratory Diseases, 100045 Beijing, China.
Insights
Broncho-Vaxom effectively reduces the frequency and duration of pediatric recurrent respiratory tract infections (RRTIs) and improves immune markers. However, it has a higher rate of non-serious adverse events, and more research is needed.
Area of Science:
- Immunology
- Pediatrics
- Pharmacology
Background:
- Recurrent respiratory tract infections (RRTIs) pose a significant health burden in children.
- Identifying effective prophylactic and therapeutic strategies for pediatric RRTIs is crucial.
Purpose of the Study:
- To assess the efficacy and safety of Broncho-Vaxom in managing pediatric RRTIs.
- To synthesize evidence from randomized controlled trials (RCTs) on Broncho-Vaxom for RRTIs.
Main Methods:
- A systematic meta-analysis of published RCTs was conducted.
- Searches were performed across multiple databases up to January 2017.
- Risk of bias and GRADE assessment were utilized.
Main Results:
- Broncho-Vaxom significantly reduced the frequency of respiratory infections compared to controls.
- Improvements were observed in antibiotic course duration, symptom severity, immunoglobulin levels, and T-lymphocyte subsets.
- Higher rates of adverse events were noted, though they were not serious.
Conclusions:
- Broncho-Vaxom demonstrates good efficacy as an adjunct therapy for pediatric RRTIs.
- The current evidence level is low, necessitating further high-quality international multicenter trials.
- Further research should focus on confirming efficacy and safety profiles.
Objectives:
Assess the efficacy and safety of Broncho-Vaxom in pediatric recurrent respiratory tract infections (RRTIs).
Methods:
Published randomized controlled trials (RCTs) of Broncho-Vaxom for pediatric RRTI were searched using PubMed, Embase, Cochrane Library, CBM, CNKI, WanFang Data, and VIP databases up to January 2017. Risk of bias was evaluated in accordance to the guidelines of the Cochrane collaboration and the level of evidence was graded according to the GRADE.
Results:
53 RCTs involving 4851 pediatric patients were included in this meta-analysis. It showed that Broncho-Vaxom was positively correlated with a reduction in the frequency of respiratory infection [MD=-2.33, 95% CI (-2.75, -1.90), P<0.00001] compared to the control group. The Broncho-Vaxom group was more effective than control groups in relation to the duration of antibiotics course, infections, fever, cough, and wheezing, increasing serum immunoglobulin levels (IgG, IgA or IgM), and T-lymphocytes subtype (CD3+, CD4+, or CD8+). However, Broncho-Vaxom had higher adverse event rates [RR=1.39, 95% CI (1.02, 1.88), P=0.04]; these were not serious and did not influence the treatment course.
Conclusion:
Broncho-Vaxom shows a good efficacy for pediatric RRTIs on the basis of routine therapy (e.g. anti-infection and antiviral therapy). However, the level of evidence was low and more international multicenter clinical trials are needed to explore the efficacy and safety of Broncho-Vaxom.
Related Concept Videos
01:17Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:30Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:31Common Respiratory Disorders
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
01:16Drugs Used in Upper Respiratory Disorders: Overview
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
01:26COPD: Management Using Bronchodilators and Corticosteroids
01:30Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....