Association between α-Klotho and Deep White Matter Lesions in the Brain: A Pilot Case Control Study Using Brain MRI.

Area of Science:

• Neuroscience
• Gerontology
• Biochemistry

Background:

• The anti-aging protein, alpha-Klotho (α-Klotho), is implicated in cognitive decline and dementia.
• The precise role of α-Klotho within the brain remains under-investigated.

Purpose of the Study:

• To investigate the association between α-Klotho levels and cognitive decline.
• To examine the relationship between α-Klotho and cerebral deep white matter lesions (DWMLs).

Main Methods:

• 280 participants underwent brain MRI to assess DWMLs using the Fazekas scale.
• Lifestyle questionnaires and neuropsychological tests were administered.
• Blood α-Klotho levels were measured and retrospectively correlated with DWMLs and cognitive function.

Main Results:

• α-Klotho levels significantly decreased with increasing grades of DWMLs.
• α-Klotho levels correlated with higher brain function tests, including the Mini-Mental State Examination and word fluency.
• Low α-Klotho levels were associated with a significantly higher odds ratio for high-grade DWMLs, even after adjustments.

Conclusions:

• Reduced blood α-Klotho levels correlate with cerebral DWML severity.
• Lower α-Klotho is an independent risk factor for cognitive decline.
• α-Klotho may serve as a valuable clinical marker for vascular cognitive impairment.