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Related Concept Videos

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Master Transcription Regulators

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
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Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry
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Mef2 and the skeletal muscle differentiation program.

Michael V Taylor1, Simon M Hughes2

  • 1School of Biosciences, Sir Martin Evans Building, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.

Seminars in Cell & Developmental Biology
|November 21, 2017
PubMed
Summary
This summary is machine-generated.

Myocyte enhancer factor 2 (Mef2) is crucial for muscle gene expression and development. This review highlights Mef2

Keywords:
Alternative splicingDifferentiationGene expression networkMef2Protein interactionsRegenerationSkeletal muscle development

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • Myocyte enhancer factor 2 (Mef2) is a key transcription factor regulating muscle gene expression.
  • Mef2 interacts with MyoD-family proteins to control muscle cell differentiation.
  • Mef2 plays vital roles in muscle development and regeneration across species.

Purpose of the Study:

  • To review the critical findings on Mef2 in skeletal muscle from its discovery to the present.
  • To highlight the in vivo functions and regulatory mechanisms of Mef2.
  • To identify current uncertainties and future research directions regarding Mef2.

Main Methods:

  • Literature review of Mef2 research.
  • Analysis of Mef2's role in gene expression networks.
  • Examination of Mef2's spatiotemporal regulation.

Main Results:

  • Mef2 acts as a central regulator in the muscle differentiation gene network.
  • Mef2 activity requires precise temporal and spatial control for proper muscle development.
  • Mef2's complex nature, involving different protein forms and regulation, presents areas for further study.

Conclusions:

  • Mef2 is indispensable for skeletal muscle development and regeneration.
  • Understanding Mef2's regulatory network is key to deciphering muscle differentiation.
  • Further research is needed to fully elucidate the diverse Mef2 proteins and their regulation.