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Related Experiment Video

Updated: Feb 18, 2026

Neutrophil Extracellular Traps Generated by Low Density Neutrophils Obtained from Peritoneal Lavage Fluid Mediate Tumor Cell Growth and Attachment
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Neutrophil elastase in the tumor microenvironment.

Irina Lerman1, Stephen R Hammes1

  • 1Department of Medicine, Division of Endocrinology and Metabolism, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave., Rochester, NY 14642, United States.

Steroids
|November 21, 2017
PubMed
Summary

Cancer accelerates myeloid cell production, fueling tumor growth and metastasis. Neutrophil elastase, secreted by myeloid cells, drives tumorigenesis and metastasis, suggesting inhibitors could be a cancer therapy.

Keywords:
Myeloid derived suppressor cells (MDSC)Neutrophil elastaseProstate cancerTumor microenvironment

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Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Cancer accelerates myeloid cell production in bone marrow.
  • Neutrophils and myeloid-derived suppressor cells (MDSCs) correlate with tumor progression.
  • Cancer hijacks the immune system to promote growth and metastasis.

Purpose of the Study:

  • To review evidence of neutrophil elastase as a cancer stimulatory factor.
  • To examine mechanisms by which neutrophil elastase facilitates tumor growth and metastasis.
  • To discuss the potential of neutrophil elastase inhibitors in cancer therapy.

Main Methods:

  • Review of preclinical studies on genetic deletion and pharmacological inhibition of neutrophil elastase.
  • Analysis of mechanisms of neutrophil elastase and neutrophil extracellular traps (NETs) in the tumor microenvironment.
  • Examination of the role of neutrophil elastase in primary tumor growth and metastasis.

Main Results:

  • Neutrophil elastase and NETs are secreted in response to tumor microenvironment cues.
  • Genetic deletion and pharmacological inhibition of neutrophil elastase reduce tumor burden and metastasis.
  • Neutrophil elastase may drive tumorigenesis, primary tumor growth, and metastasis.

Conclusions:

  • Neutrophil elastase is a key factor in cancer progression and metastasis.
  • Targeting neutrophil elastase with inhibitors shows therapeutic potential for cancer treatment.