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Updated: Feb 18, 2026

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
Published on: May 31, 2024
CLOSTRIDIUM PERFRINGENS PANOPHTHALMITIS AFTER INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTION
Swarupa Kancherla1, Ahmara Ross1,2, Susan T Stefko1
1Eye and Ear Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and.
Purpose:
This report describes a fulminant infection with Clostridium perfringens after an intravitreal anti-vascular endothelial growth factor injection.
Methods:
This is a retrospective case review.
Results:
Our patient's rapid infection eventually led to enucleation, despite broad-spectrum antibiotic therapy.
Conclusion:
Reporting rare causes and common clinical findings of C. perfringens ocular infection may lead to earlier detection and intervention.
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