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Treatment Planning for Radiation Therapy.

Michael MacManus1, Sarah Everitt1

  • 1Department of Radiation Oncology, Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia; The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3010, Australia.

PET Clinics
|November 22, 2017
PubMed
Summary

Positron emission tomography (PET) scanning is crucial for managing lung cancer patients undergoing radiotherapy. Advanced PET imaging improves staging, treatment selection, and radiotherapy planning, enhancing patient survival rates.

Keywords:
CT scanningChemotherapyLung cancerPETRadiation therapySurgery

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiotherapy

Background:

  • Positron emission tomography (PET) scanning is vital in managing lung cancer patients.
  • It aids in planning curative-intent radiotherapy and has improved survival outcomes.
  • 18F-fluorodeoxyglucose-PET is the primary tool for staging and radiotherapy planning in unresectable non-small cell lung cancer.

Purpose of the Study:

  • To highlight the critical role of PET scanning in lung cancer management.
  • To discuss advancements in PET tracers for imaging proliferation and hypoxia.
  • To explore the potential of response-adapted therapy using interim PET scans.

Main Methods:

  • Review of current applications of 18F-fluorodeoxyglucose-PET in lung cancer.
  • Discussion of novel PET tracers (e.g., 18F-fluorothymidine) for tumor characteristics.
  • Exploration of interim PET scan utility in treatment adaptation.

Main Results:

  • PET scanning significantly impacts radiotherapy planning and patient selection.
  • 18F-fluorodeoxyglucose-PET is essential for unresectable non-small cell lung cancer management.
  • Emerging tracers offer new avenues for assessing tumor biology and response.

Conclusions:

  • PET imaging is indispensable for optimizing lung cancer treatment strategies.
  • Continued development of PET tracers promises further improvements in patient care.
  • Response-adapted therapy guided by interim PET scans may enhance local disease control.