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Updated: Feb 18, 2026
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
The Dynamics of the Gut Microbiome in Multiple Sclerosis in Relation to Disease
Ellen M Mowry1, Justin D Glenn2
1Department of Neurology, Johns Hopkins School of Medicine, 600 North Wolfe Street, Pathology 627, Baltimore, MD 21287, USA.
Abstract:
Multiple sclerosis (MS) is a neuroinflammatory autoimmune disease of unknown etiology, although genetic components and environmental triggers are thought to collude to commence pathogenesis. Numerous investigations are now demonstrating the role of the gut microbiota in neuroinflammation and how alterations in its content may be associated with MS disease. This article explores the studies using MS rodent models to determine the roles of gut bacteria in neuroinflammatory disease, evaluate the evidence linking gut bacterial dysbiosis and MS, and give insight into potential MS therapies targeting the gut microbiota currently under investigation.
Insights
Multiple sclerosis (MS) is a neuroinflammatory autoimmune disease. Research shows gut bacteria alterations may link to MS, with potential therapies targeting the gut microbiota under investigation.
Area of Science:
- Neuroimmunology
- Microbiome Research
- Autoimmune Diseases
Background:
- Multiple sclerosis (MS) is a complex neuroinflammatory autoimmune condition with unknown causes.
- Genetic and environmental factors are implicated in MS pathogenesis.
- Emerging research highlights the gut microbiota's role in neuroinflammation and its potential connection to MS.
Purpose of the Study:
- To explore studies on gut bacteria in MS rodent models.
- To evaluate the evidence linking gut dysbiosis with MS.
- To provide insights into potential gut microbiota-targeted MS therapies.
Main Methods:
- Review of scientific literature focusing on MS rodent models.
- Analysis of studies investigating the gut microbiota composition in MS.
- Examination of research on therapeutic interventions targeting the gut microbiome for MS.
Main Results:
- Gut microbiota alterations are increasingly associated with neuroinflammation in MS.
- Rodent models provide valuable insights into the mechanisms linking gut bacteria and MS.
- Evidence suggests gut dysbiosis plays a significant role in MS pathogenesis.
Conclusions:
- The gut microbiota is a critical factor in MS neuroinflammation.
- Targeting the gut microbiota presents a promising therapeutic avenue for MS.
- Further research into gut-brain axis interactions is crucial for MS management.
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