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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Spinal Cord MRI in Multiple Sclerosis.

Alexandra Muccilli1, Estelle Seyman2, Jiwon Oh3

  • 1Division of Neurology, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada; Division of Neurology, Centre Hospitalier de L'Université de Montréal, Université de Montréal, 1058 Saint-Denis Street, Montreal, Quebec H2X 3J4, Canada.

Neurologic Clinics
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Summary
This summary is machine-generated.

Spinal cord MRI aids in multiple sclerosis (MS) diagnosis and prognosis. Advanced quantitative MRI techniques offer insights into neurodegeneration and may serve as future clinical biomarkers.

Keywords:
Clinical usefulnessMRIMultiple sclerosisPredictionQuantitative techniquesSpinal cord

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Area of Science:

  • Neurology
  • Radiology
  • Biomedical Imaging

Background:

  • Spinal cord (SC) magnetic resonance imaging (MRI) is crucial for multiple sclerosis (MS) management.
  • Conventional SC MRI provides diagnostic and prognostic information in clinical practice.
  • Advanced SC MRI techniques assess structural and functional integrity.

Purpose of the Study:

  • To evaluate the utility of advanced, quantitative SC MRI measures in MS.
  • To explore the potential of these techniques in understanding microstructural and functional changes.
  • To identify their future role as biomarkers in clinical trials and practice.

Main Methods:

  • Utilizing conventional SC MRI for diagnosis and prognosis.
  • Employing advanced quantitative SC MRI techniques in investigational settings.
  • Assessing structural and functional integrity of the SC.

Main Results:

  • Conventional SC MRI demonstrates diagnostic and prognostic value in MS.
  • Advanced SC MRI techniques provide insights into SC microstructural and functional changes.
  • These changes are relevant to disability experienced by MS patients.

Conclusions:

  • SC MRI is valuable in both clinical and research settings for MS.
  • Advanced quantitative SC MRI techniques show promise as biomarkers for neurodegeneration and neuroprotection.
  • Further development could integrate these advanced techniques into clinical trials and routine patient care.