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L Maione1, S Christin-Maître2, P Chanson3

  • 1Université Paris-Sud, Orsay 91400, France; Service d'endocrinologie et des maladies de la reproduction, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 94275 Le Kremlin-Bicêtre, France; Service de génétique moléculaire, pharmacogénétique et hormonologie, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 94275 Le Kremlin-Bicêtre, France.

Annales D'Endocrinologie
|November 22, 2017
PubMed
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This summary is machine-generated.

The Kisspeptin/Neurokinin B (Kp/NkB) system regulates the gonadotrope axis, impacting puberty and fertility. Targeting this system shows promise for treating reproductive disorders and menopausal symptoms.

Area of Science:

  • Neuroendocrinology
  • Reproductive Biology
  • Pharmacology

Background:

  • The hypothalamic gonadotropin-releasing hormone (GnRH) regulates gonadal functions.
  • The Kisspeptin/Neurokinin B (Kp/NkB) system is the primary regulator of GnRH neurons.
  • This system mediates feedback from sex steroids, prolactin, and metabolic signals.

Purpose of the Study:

  • To review the role of the Kp/NkB system in reproductive functions and related disorders.
  • To explore the therapeutic potential of Kp/NkB modulators.

Main Methods:

  • Literature review of studies on the Kp/NkB system.
  • Analysis of clinical data on Kp/NkB-targeted therapies.
  • Examination of the mechanism of NkB in menopausal hot flashes.
Keywords:
Bouffées de chaleur de la ménopauseCongenital hypogonadotropic hypogonadismGnRHHypogonadisme hypogonadotrophique congénitalKisspeptinKisspeptineNeurokinin BNeurokinine BPost-menopausal hot flushesclimatére

Related Experiment Videos

Main Results:

  • Kp/NkB system dysfunction causes hypogonadotropic hypogonadism, precocious puberty, amenorrhea, and hyperprolactinemia.
  • NkB directly contributes to menopausal hot flashes.
  • Kp/NkB agonists/antagonists are under clinical evaluation for various conditions.

Conclusions:

  • The Kp/NkB system is crucial for reproductive health and presents therapeutic targets.
  • NkB antagonists offer a promising treatment for menopausal vasomotor symptoms.