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Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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Related Experiment Video

Updated: Feb 18, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Identifying and Characterizing circRNA-Protein Interaction.

William W Du^1,2, Chao Zhang^1,2, Weining Yang¹

¹Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto.

|November 22, 2017

Summary

This summary is machine-generated.

Circular RNAs (circRNAs) are abundant but their functions are unclear. This review explores how circRNA-protein interactions influence cellular processes and proposes a dynamic model for their roles.

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Last Updated: Feb 18, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

Area of Science:

Molecular Biology
Genetics
Biochemistry

Background:

Circular RNAs (circRNAs) are prevalent in eukaryotic transcriptomes, yet their biological functions are largely uncharacterized.
While known to act as miRNA sponges, their roles in protein interaction remain an active area of investigation.

Purpose of the Study:

To review the biological implications and functions of circRNA-protein interactions.
To present a dynamic model illustrating circRNA-protein interactions across different biological contexts.

Main Methods:

Literature review of studies investigating circRNA-protein interactions.
Analysis of existing data on circRNA binding, sequestration, and scaffolding of proteins.
Synthesis of findings to propose a dynamic interaction model.

Main Results:

CircRNAs can bind, store, sort, and sequester proteins to specific subcellular locations.
CircRNAs function as dynamic scaffolding molecules, modulating protein-protein interactions.
CircRNA-protein interactions exhibit dynamic behavior across various tissues, developmental stages, and physiological conditions.

Conclusions:

CircRNA-protein interactions are crucial for understanding circRNA functional diversity.
Further development of techniques to identify and characterize these dynamic interactions is essential.
Elucidating these mechanisms will advance knowledge of gene expression regulation.