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Potential Significance of Targeting Ferroptosis for Intervention of Diabetic Cardiomyopathy
Qian Lei1,2, Burton B Yang3, Juanjuan Lyu4,5
1Anesthesia and Operation Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Background:
Diabetes represents a significant global health concern, with diabetic cardiomyopathy (DCM) emerging as a primary cause of mortality among individuals with diabetes. Despite the prevalence of DCM, advancements in therapeutic and preventative strategies remain constrained.
Methods:
Recent studies were reviewed to provide a comprehensive summary of pathogenesis and clinical treatment of DCM, effect of ferroptosis, and potential value of ferroptosis inhibitors in DCM intervention.
Results:
A growing body of research indicates that oxidative stress, inflammatory reactions, and other factors play a role in the onset and progression of DCM. Oxidative stress within cardiomyocytes is a primary mechanism implicated in the development of DCM, whereby heightened intracellular reactive oxygen species (ROS) facilitate cell death via ferroptosis. Ferroptosis inhibitors hold great promise as therapeutic agents.
Conclusions:
This review provides an overview of the involvement of iron homeostasis regulation, oxidative stress, and ferroptosis in DCM, and the significance of ferroptosis in the prevention and treatment of DCM.
Insights
Diabetic cardiomyopathy (DCM) is a serious diabetes complication. Ferroptosis, a cell death pathway driven by oxidative stress, offers a promising target for new DCM treatments.
Area of Science:
- Cardiovascular Research
- Metabolic Disorders
- Cellular Biology
Background:
- Diabetic cardiomyopathy (DCM) is a major cause of mortality in diabetes patients.
- Current therapeutic and preventative strategies for DCM are limited.
- Understanding DCM pathogenesis is crucial for developing effective treatments.
Purpose of the Study:
- To summarize the pathogenesis and clinical treatment of DCM.
- To review the role of ferroptosis in DCM.
- To explore the potential of ferroptosis inhibitors for DCM intervention.
Main Methods:
- Literature review of recent studies on DCM.
- Analysis of the impact of ferroptosis on DCM.
- Evaluation of ferroptosis inhibitors as therapeutic agents.
Main Results:
- Oxidative stress and inflammation contribute to DCM development.
- Increased reactive oxygen species (ROS) in cardiomyocytes induce cell death via ferroptosis.
- Ferroptosis inhibitors show significant therapeutic potential for DCM.
Conclusions:
- Iron homeostasis, oxidative stress, and ferroptosis are key factors in DCM.
- Ferroptosis plays a critical role in the prevention and treatment of DCM.
- Targeting ferroptosis presents a promising avenue for managing diabetic cardiomyopathy.
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