Quantitative Imaging for Targeted Radionuclide Therapy Dosimetry - Technical Review.

Area of Science:

• Nuclear Medicine
• Radiotherapy
• Medical Imaging

Background:

• Targeted radionuclide therapy (TRT) offers a promising approach for cancer treatment.
• Accurate internal dosimetry, based on patient-specific data, is crucial for optimizing TRT efficacy and minimizing toxicity.
• Radionuclide imaging is essential for determining tracer distribution and calculating organ-absorbed doses.

Purpose of the Study:

• To review the fundamental principles of TRT.
• To discuss recent advancements in radionuclide imaging for theranostic agents.
• To highlight the potential of these imaging techniques in enhancing personalized TRT dosimetry.

Main Methods:

• Review of basic principles of Targeted Radionuclide Therapy (TRT).
• Analysis of current and emerging radionuclide imaging modalities (planar scintigraphy, SPECT, PET, bremsstrahlung imaging).
• Evaluation of imaging techniques for quantifying tracer distribution and supporting personalized dosimetry.

Main Results:

• Planar scintigraphy remains a common imaging method in TRT.
• SPECT, PET, and bremsstrahlung imaging demonstrate significant potential for improving quantitative accuracy in dosimetry.
• These advanced techniques are key to refining patient-specific dose calculations.

Conclusions:

• Personalized dosimetry is vital for successful TRT.
• Advancements in radionuclide imaging are critical for improving the accuracy and effectiveness of TRT.
• Future applications of SPECT, PET, and bremsstrahlung imaging will likely enhance personalized cancer therapy.