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Gene expression microarray data from mouse cerebrum treated with rTMS for 30 days.

Tetsurou Ikeda1,2, Satoru Kobayashi3, Chikao Morimoto2

  • 1Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

Data in Brief
|November 22, 2017
PubMed
Summary
This summary is machine-generated.

Repetitive transcranial magnetic stimulation (rTMS) impacts gene expression in mouse brains. This study provides data on how rTMS affects ER stress and neurotransmitter transporter genes.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique.
  • Previous research indicates rTMS influences neurotransmitter systems and cellular stress responses.
  • Understanding the genetic underpinnings of rTMS effects is crucial for therapeutic applications.

Purpose of the Study:

  • To provide comprehensive gene expression data following rTMS treatment in mice.
  • To identify specific genes regulated by rTMS, focusing on ER stress and neurotransmitter transporters.

Main Methods:

  • Gene expression profiling using Affymetrix GeneChip microarrays.
  • Treatment of mouse cerebrum with rTMS for 30 days.
  • Analysis of data presented in accompanying tables (Tables 1-10).

Main Results:

  • Identification of significant changes in gene expression related to ER stress pathways.
  • Modulation of genes encoding glutamate, GABA, and glycine transporters observed.
  • Detailed gene expression data is available in supplementary tables.

Conclusions:

  • rTMS treatment alters the expression of key genes involved in cellular stress and neurotransmission.
  • The provided data offers valuable insights into the molecular mechanisms of rTMS.
  • This dataset can facilitate further research into rTMS as a therapeutic intervention.