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Related Experiment Video

Updated: Feb 18, 2026

Terahertz Imaging and Characterization Protocol for Freshly Excised Breast Cancer Tumors

Terahertz Imaging and Characterization Protocol for Freshly Excised Breast Cancer Tumors

Published on: April 5, 2020

Characterization of photon-counting multislit breast tomosynthesis.

Karl Berggren^1,2, Björn Cederström², Mats Lundqvist²

¹Physics of Medical Imaging, Royal Institute of Technology, AlbaNova University Center, 106 91, Stockholm, Sweden.

Medical Physics

|November 22, 2017

Summary

This study characterizes a novel spectral breast tomosynthesis system using a photon-counting detector. The system achieves high image quality at low doses, promising improved cancer detection and reduced callbacks in screening mammography.

Keywords:

ASF DQE MTF photon-counting spectral imaging tomosynthesis

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Area of Science:

Medical Imaging
Radiology
Photon-Counting Detectors

Background:

Breast tomosynthesis offers improved sensitivity and specificity over 2D mammography.
Spectral imaging can further enhance diagnostic capabilities by providing material-specific information.

Purpose of the Study:

To characterize a prototype multislit breast tomosynthesis system with single-scan spectral imaging capabilities.
To evaluate image quality metrics including modulation transfer function (MTF), noise power spectrum, and detective quantum efficiency (DQE).

Main Methods:

Utilized a dual-threshold photon-counting detector with 21 collimated line detectors.
Evaluated three reconstruction methods: simple back-projection, filtered back-projection, and iterative algebraic reconstruction.
Assessed image quality using MTF, normalized noise-power spectrum, DQE, and artifact spread-function (ASF) across two energy bins.

Main Results:

Negligible energy dependence on resolution observed (MTF varied by reconstruction method).
Zero-frequency DQE was 0.72, indicating high efficiency.
Scantimes ranged from 4s to 16.5s, with a high-energy bin fraction of 59%.

Conclusions:

The characterized system produces high-quality spectral tomosynthesis images at low doses.
High DQE supports its utility in low-dose screening applications.
Single-scan spectral imaging enables advanced applications like material decomposition and contrast-enhanced imaging.