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Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy

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Published on: July 20, 2022

A Portable Stiffness Measurement System.

Onejae Sul¹, Eunsuk Choi², Seung-Beck Lee^3,4

¹Institute of Nano Science and Technology, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea. ojsul@hanyang.ac.kr.

Sensors (Basel, Switzerland)

|November 22, 2017

Summary

A novel indentation method measures stiffness by analyzing lateral deformation. This technique enhances material differentiation and prevents measurement saturation, offering a versatile approach for various materials.

Keywords:

Sneddon’s solution portable system stiffness measurement

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Area of Science:

Materials Science
Mechanical Engineering
Biophysics

Background:

Accurate stiffness measurement is crucial for material characterization and understanding mechanical properties.
Existing methods may face challenges in differentiating similar hardness materials or avoiding saturation.

Purpose of the Study:

To introduce a new stiffness measurement technique based on lateral deformation profiles.
To develop a portable system for implementing this novel measurement method.

Main Methods:

The proposed method uses a force measurement module situated between two equidistant touch sensing modules.
Lateral deformation is analyzed under indentation to determine stiffness.
Adjustable parameters include touch module separation, indenter protrusion, and force sensing module spring constant to tailor the sensing range.

Main Results:

The method successfully differentiates stiffness between objects of similar hardness.
Measurement saturation is avoided by adjusting system parameters.
A portable measurement system was developed and validated using polymer foams and human skin.

Conclusions:

The novel indentation method provides a tunable and effective approach for stiffness measurement.
The portable system demonstrates practical applicability for diverse material testing.