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Recurrent meningitis in a black man.

J F Cooper1, D W Gregory

  • 1Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

Southern Medical Journal
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

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Recurrent Neisseria meningitidis meningitis in a patient with a complement component 6 deficiency highlights impaired bacterial killing. This deficiency increases susceptibility to Neisseria infections despite normal opsonization.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Genetics

Background:

  • Recurrent bacterial meningitis poses significant health challenges.
  • Neisseria meningitidis is a common cause of bacterial meningitis.
  • Complement system deficiencies are associated with increased infection susceptibility.

Observation:

  • A 43-year-old male experienced recurrent acute bacterial meningitis caused by Neisseria meningitidis.
  • The patient presented with a history of four meningitis episodes since age 27.
  • Serum analysis revealed undetectable levels of the sixth complement component (C6).

Findings:

  • Congenital absence of C6 impairs the direct killing of Neisseria species.
  • Complement deficiency affects the terminal pathway of the complement system.

Related Experiment Videos

  • While opsonization is normal, direct bacterial lysis by serum is compromised in C6 deficiency.

    • Implications:

    • Patients with C6 deficiency are at high risk for recurrent Neisseria infections.
    • Current meningococcal vaccines may not fully address the underlying complement defect.
    • Further research is needed on prophylactic strategies, including the role of antibiotics, for complement-deficient individuals.