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The relationship between soluble CD40 ligand level and atherosclerosis in white-coat hypertension

Yu-Qing Huang1, L I Jie1, Ji-Yan Chen1

  • 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, 510080, China.

Journal of Human Hypertension
|November 23, 2017
PubMed

Insights

Plasma soluble CD40 ligand (sCD40L) is elevated in hypertension (HT) and white-coat hypertension (WCH). Higher sCD40L levels correlate with increased carotid intima-media thickness (CIMT), suggesting it may be a marker for atherosclerosis.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Hypertension Studies

Background:

  • Hypertension and white-coat hypertension are associated with increased cardiovascular risk.
  • Carotid intima-media thickness (CIMT) is a marker of subclinical atherosclerosis.
  • Soluble CD40 ligand (sCD40L) is implicated in inflammatory processes relevant to atherosclerosis.

Purpose of the Study:

  • To investigate plasma sCD40L levels in patients with hypertension (HT), white-coat hypertension (WCH), and healthy controls.
  • To examine the relationship between sCD40L and CIMT across these groups.
  • To determine if sCD40L is a risk factor for increased CIMT.

Main Methods:

  • Cross-sectional study involving 35 HT patients, 35 WCH patients, and 35 healthy controls.
  • Measurement of plasma sCD40L levels.
  • Assessment of CIMT to categorize participants into normal, subclinical atherosclerosis, and atherosclerosis groups.

Main Results:

  • Plasma sCD40L levels were highest in the HT group, followed by the WCH group, and lowest in controls.
  • Elevated sCD40L was observed in the atherosclerosis group compared to subclinical atherosclerosis and control groups.
  • In WCH patients, sCD40L positively correlated with CIMT and systolic blood pressure.
  • sCD40L was identified as a significant risk factor for increased CIMT (OR 1.504, P < 0.001).

Conclusions:

  • Plasma sCD40L levels are significantly higher in individuals with WCH and HT compared to healthy controls.
  • sCD40L is positively associated with CIMT and may serve as a non-invasive biomarker for atherosclerosis in WCH patients.

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